Handloading dangerous game ammo is not inherently different than loading for other game species, the stakes are just higher, which means reliability is crucial.
I’ve been told I’m crazy, near suicidal, for using handloaded ammunition on hunts for dangerous game. “You can’t rely on that stuff! You’re going to get killed.” Nonsense; nothing could be further from the truth. Just as you trust yourself to pull the trigger on any dangerous game animal, because you’ve honed your skills as a shooter, you must trust your skills as a reloader to produce dangerous game ammo that is as reliable, if not more reliable, than the factory stuff.
Not that you’d ever skimp on your reloading procedure, irrespective of intended purpose, dangerous game ammo requires a special level of detail. What we’re looking for here is utter reliability and uniformity, so the last thing you’ll be concerned with when the excrement hits the oscillator is your ammunition. I like to be ultra-critical of the condition of brass if I’m using once- or twice-fired, checking diligently for issues with the rim and/or cracks in the neck area. If you’re using new brass, and there’s no reason not to, I like to make sure all of it is trimmed to a uniform length, and that all the flash holes are touched up.
img source: https://gundigest.com/gear-ammo/reloading/reloading-load-dangerous-game-ammo